General Information

  • ID:  hor000012
  • Uniprot ID:  NA
  • Protein name:  Adipokinetic hormone
  • Gene name:  NA
  • Organism:  Drosophila melanogaster
  • Family:  AKH/HRTH/RPCH family
  • Source:  animal
  • Expression:  cells in the corpora cardiaca
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  ELTFSPDW
  • Length:  8
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid amide;T8 Tryptophan amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Lead to an activation of TAG lipase which makes lipids available for the production of energy to contract the flight muscles.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000012_AF2.pdbhor000012_ESM.pdb

Physical Information

Mass: 111910 Formula: C47H63N9O15
Absent amino acids: ACGHIKMNQRVY Common amino acids: DEFLPSTW
pI: 3.55 Basic residues: 0
Polar residues: 2 Hydrophobic residues: 3
Hydrophobicity: -55 Boman Index: -1127
Half-Life: 1 hour Half-Life Yeast: 30 min
Half-Life E.Coli: >10 hour Aliphatic Index 48.75
Instability Index: 6967.5 Extinction Coefficient cystines: 5500
Absorbance 280nm: 785.71

Literature

  • PubMed ID:  2117437
  • Title:  The Fruitfly Drosophila Melanogaster Contains a Novel Charged Adipokinetic-Hormone-Family Peptide